(1) |
Porter, M. D.; Chau, L. K. "Porous-polymer-film calcium-ion sensor and method of using it" 1991, US Patent 4,992,382.
This sensor and method has a Ca-sensitive reagent, calcichrome, immobilized on a porous polymer film. The reaction of the Ca-sensitive reagent to the Ca(II) is then measured and concn. detd. as a function of the reaction.
|
(2) |
Porter, M. D.; Jones, T. P.; Coldiron, S. J. "Dual-wavelength photometer and fiber optic sensor probe", 1994, US Patent 5,307,146.
A dual wavelength optical sensor for measuring chemical properties of a particular quantity, the optical sensor including a sensor probe having a thin sensing film whose optical characteristics are responsive to the chemical properties of the measured quantity.
|
(3) |
Porter, M. D.; Deinhammer, R. S.; Shimazu, K. "Ion chromatographic separations using step and linear voltage waveforms with a charge-controllable polymeric stationary phase", 1994, WO Patent 1994/000215.
A method and apparatus for chromatographic separations comprising a conductive-polymer stationary phase for controlled interaction with ionic species. The conductive polymer stationary phase is held at an initial voltage while analyte containing ionic species is added. The ionic species interact with and are held by the stationary phase. Voltage across the stationary phase is varied by linear or step waveforms which alters the stationary phase charge characteristics. Ionic species are selectively released from the stationary phase as its charge characteristics change due to the individual charges of each ionic species. Ionic species released from the stationary phase are flushed from the column by an ionic mobile phase.
|
(4) |
Porter, M. D.; Hoffman, D. K.; Zhong, C.-J. "Fluid pumping system based on electrochemically-induced surface tension changes", 1995, US Patent 5,472,577.
A pump for exerting a pumping force on a fluid in an attached conduit, the pump being actuated by a voltage from a power supply, the pump comprising a liquid metal pool, a containment vessel for confining the pool, an inner tubular member in hydraulic contact with the attached conduit and with an open end disposed in the pool to divide a free upper surface of the pool into an actuation surface and a working surface, an electrolyte in contact with the actuation surface, an electrode in contact with the electrolyte, and an electrode in contact with the pool, such that application of a voltage to the electrodes causes a surface tension change in the actuation surface and a resulting height change in the working surface, whereby a pumping action is transferred to the fluid in the attached conduit.
|
(5) |
Porter, M. D.; Weisshaar, D. E. "Electrochemical method of controlling thiolate coverage on a conductive substrate such as gold", 1997, US Patent 5,635,047.
A method for forming a partial monomolecular layer of a thiolate having the formula, XRS.sup.-, wherein R is a member selected from the group consisting of linear chain hydrocarbons, branched chain hydrocarbons and aromatics, and X is a member selected from the group consisting of OH, COOH, CH.sub.3, CF.sub.3 (CF.sub.2).sub.7, inorganic complexes with thiol ligands, organometallic compounds, cyclodextrins, and crown ethers, upon a substrate, which comprises determining the constant voltage necessary to be applied to provide a desired extent of coverage of said thiolate upon said substrate, providing an electrochemical system for forming said thiolate partial monomolecular layer upon said substrate and applying said constant voltage for a time sufficient to establish a redox equilibrium, which deposits the thiolate partial monomolecular layer upon said substrate
|
(6) |
Henderson, E. R.; Mosher, C. L.; Jones, V. W.; Green, J.-B. D.; Porter, M. D. "Analytical method using modified scanning probes", 1998, US Patent 5,763,768.
The present invention provides a method of analyzing for a specific material in a sample using a sensor including a resonating member having resonating properties. The resonating member has a probe and a known material is disposed on or forms the probe. The method includes the steps of positioning the sensor proximate to the sample, detecting a force dependent change in the resonance properties of the sensor, and confirming the presence of the specific material based on the identity of the known material and the detection of a resonance change.
|
(7) |
Porter, M. D.; Weisshaar, D. E. "Electrochemical method of controlling thiolate coverage on a conductive substrate such as gold", 1998, US Patent 5,827,417.
An electrochemical method for forming a partial monomolecular layer of a predetermined extent of coverage of a thiolate of the formula, XRS--, therein R can be a linear or branched chain hydrocarbon or an aromatic or the like and X can be any compatible end group, e.g., OH, COOH, CH.sub.3 or the like, upon a substrate such as gold, which involves applying in an electrochemical system a constant voltage preselected to yield the desired predetermined extent of coverage. |
(8) |
Porter, M. D.; Jones, V. W.; Mosher, C. L.; Henderson, E. "Height referencing biochemical cassette", 2000, US Patent 6,146,899.
A height referencing biochemical cassette comprising of a surface suitable to act as a coupling agent, a height referencing indicator, and molecules bonded to the surface. This cassette is a capable of use to test for bonding to these molecules through measuring the height difference between the indicator and the surface. This invention provides an efficient means to quickly and easily test for bonding of molecules to other molecules.
|
(9) |
Shinar, R.; Liu, G.; Porter, M. D. "Chemical sensor and coating for same", 2001, US Patent 6,432,362.
A chemical sensor, comprising: a substrate; at least two electrodes connected to the substrate; and a blended coating positioned over the substrate and at least one of the electrodes, the blended coating comprising at least two different materials, wherein the combination of the substrate and the blended coating has a first resonant frequency in the presence of a chemical having a first concentration and a second resonant frequency in the presence of the chemical having a second concentration.
|
(10) |
Shinar, R.; Liu, G.; Porter, M. D. “"Chemical sensor and coating for same", 2001, US Patent 6,237,397.
An acoustic wave-based chemical sensor, comprising: a substrate; at least two electrodes connected to the substrate; and a coating positioned over the substrate and at least one of the electrodes, the coating consisting of graphite microparticles.
|
(11) |
Vaidya, B.; Porter, M. D.; Shinar, R.; Lipert, R. J. "Chemical sensor with block copolymer coatings", 2003, CA Patent 2,369,720.
Block copolymer or graft copolymer coatings and blends of block copolymers o r graft copolymers with homopolymers and resins are used as a chemical absorption layer on a high performance, mass-sensitive, acoustic wave-based sensing device. The use of block copolymer coating materials containing polymer blocks with high and low glass transition temperatures within the same molecule allows for tailoring of the absorption and physical characteristics of the absorptive layer on a sensor. The coatings form a composition that exhibits the necessary physical properties for use as the absorptive coating in an acoustic wave-sensing device. These materials have favorable acoustic properties over extended temperature ranges, resulting in a wider operating temperature range for acoustic wave-based sensing of volatile organic compounds. Moreover, the improved acoustic properties enable thicker coatings to be used, which increases the detection sensitivity of the sensor.
|
(12) |
Porter, M. D.; Granger, J. H. "Redox polymer nanoparticles", 2004, US Patent 7,309,723.
The invention provides nanoparticles comprising one or more redox-active species, methods of making such nanoparticles, and methods for using such nanoparticles, for example, as diagnostic agents for the detection of various analytes.
|
(13) |
Porter, M. D.; Ni, J.; Dawson, G. B.; Shinar, R.; Lipert, R. J.; Granger, M. C.; Tondra, M. "Method and apparatus for magnetoresistive monitoring of analytes in flow streams (Detection)", 2004, US Patent 6,736,978.
A method of monitoring analyte flowing in fluid streams comprising the steps of: providing a giant magnetoresistive sensor having at least one sensing element which produces electrical output signals that vary dependent on changes in the magnetic field proximate the sensing element; providing a stream including the analyte, the stream having a magnetic property dependent on the concentration and distribution of analyte therein; flowing the stream past the giant magnetoresistive sensor in sufficiently close proximity to cause the magnetic properties of the stream to produce electrical output signals from the giant magnetoresistive sensor; and monitoring the electrical signals produced by the giant magnetoresistive sensor as an indicator of at least one of an analyte concentration, an analyte distribution, and an analyte magnetic property in the stream flowing past the giant magnetoresistive sensor.
|
(14) |
Porter, M. D.; Ni, J.; Lipert, R. J.; Dawson, G. B. "Raman-active reagents and the use thereof", 2005, US Patent Application, 2005089901.
The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).
|
(15) |
Porter, M. D.; Ni, J.; Dawson, G. B.; Shinar, R.; Lipert, R. J.; Granger, M. C.; Tondra, M. "Method and apparatus for magnetoresistive monitoring of analytes in flow streams (Manipulation)" , 2007, US Patent Application, 11/620,879. |
(16) |
Porter, M. D.; Ni, J.; Dawson, G. B.; Shinar, R.; Lipert, R. J.; Granger, M. C.; Tondra, M. "Method and apparatus for magnetoresistive monitoring of analytes in flow streams (Movement)" , 2007, US Patent, 7,179,383.
A method to move a magnetizable object along a microfluidic channel comprising the step of generating a local magnetic field gradient in conjunction with a uniform magnetic field in the presence of the magnetizable object.
|